Diabetic ketoacidosis associated with atypical antipsychotic drug, clozapine treatment: Report of a case and review of literature
نویسندگان
چکیده
A b st ra ct Atypical antipsychotic drugs are associated with metabolic disturbances like weight gain, type 2 diabetes hyperglycaemia and dyslipedemia, which can result in serious health risk in patients. Diabetic ketoacidosis resulting in serious metabolic acidosis, occurring in a schizophrenic patient on treatment with clozapine is being reported to draw attention this association. Frequent monitoring of the blood sugar and lipids is advised before and during therapy with atypical antipsychotic drugs.
منابع مشابه
Diabetes mellitus associated with atypical antipsychotic medications: new case report and review of the literature.
BACKGROUND Since the introduction of atypical antipsychotic medications, beginning with clozapine in 1990, several case reports in the psychiatric literature have suggested that they might be associated with new onset of diabetes mellitus as well as with diabetic ketoacidosis. METHODS We report the case of a 38-year-old patient with schizophrenia who suddenly developed diabetes mellitus and k...
متن کاملDiabetic ketoacidosis associated with antipsychotic drugs: case reports and a review of literature.
BACKGROUND Second generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation linked to the use of SGAs. The aims of this article are to present patients with a history of psychotic disorders and of severe metabolic diabetic ketoacidosis, possibly associated with the use ...
متن کاملDiabetic ketoacidosis and severe hypertriglyceridaemia as a consequence of an atypical antipsychotic agent.
The atypical antipsychotic agent clozapine, although an effective treatment for schizophrenia, is linked with metabolic adverse effects. We report a case of diabetic ketoacidosis and very severe hypertriglyceridaemia associated with clozapine use, in a patient with type 2 diabetes mellitus, who was successfully treated with continuous insulin infusion and fluids. As clozapine proved to be the m...
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Reports of diabetes, diabetic ketoacidosis, hyperglycemia, and dyslipidemias in patients treated with atypical antipsychotics have increased in recent years. This increase has led to growing concern about a possible link between these metabolic effects and atypical antipsychotic therapy. This review article provides an overview of the evidence for an association between glucose and lipid dysreg...
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